PDR / DAILY INTELLIGENCE / 2026-10-09
LATEST FIELD NOTE / 01Protein Design Radar
追踪生成模型、序列与结构设计、实验验证和开源工具。每天从论文、实验室与产业信号中，筛出真正值得继续阅读的内容。
HighFold 1 到 4，环肽预测走到了“键级别”
我最近把 HighFold 1 到 4 连着看了一遍。四篇文章从 2024 年排到 2026 年，题目都围绕环肽结构预测，读起来很像同一个团队在持续修一处老问题。
READ FIELD NOTE ↗ESSAYS / 中文文章039
SIGNALS / 行业资讯124
RESEARCH / 精选论文217
PIPELINE STATUS● OPERATIONAL
SEC. 02
RESEARCH INDEX ↗论文雷达
Corrigendum to “AVP-GPT2: Prompt-conditioned fine-tuning of a GPT-2 protein language model for antiviral peptide identification” [Eur. J. Med. Chem. 320 (2026) 119352]
European Journal of Medicinal Chemistry / 2026-10
Protein language modelsBinders and therapeutics
Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition
Mol Syst Biol / 2026-10-08
Binders and therapeuticsEnzymes and function
SIMORGH: Ensemble-Aware Geometric Deep Learning for Apo-State and Cryptic Ligand Binding Site Prediction
bioRxiv / 2026-10-08
General
Crowdsourcing functional cell therapy binders from generative artificial intelligence
Mol Syst Biol / 2026-10-08
Binders and therapeutics
PNBind: Prediction of Nucleic Acid-Binding Sites Using Protein Structure and Protein Language Models.
PubMed / 2026 Oct 08
Structure generationProtein language modelsEnzymes and function
LoRA-N-Gly: Sequence-based Prediction of N-Linked Glycosylation Sites by Tuning Protein Language Models with Low-rank Adaptation.
PubMed / 2026 Oct 08
Protein language models